Ryanair is ceasing services from Belfast City Airport from 31 October, the airline has announced.
Passengers are advised to check with Ryanair for bookings made after the date.
It said the decision followed the airport's confirmation that a public inquiry into a planned runway extension would be further delayed.
Ryanair has been operating from George Best Belfast City Airport since 2007.
Ryanair's Michael O'Leary said that "it is very disappointing that the promised runway extension at Belfast City Airport has still not materialised more than three years after we opened the base at Belfast City".
Jobs
The company said that from November, Ryanair will switch its one Belfast City based aircraft to another European airport, with the loss of 50 Ryanair jobs.
It said that all staff will be offered relocation elsewhere in the UK or Europe.
On Tuesday, Katy Best, business development director at George Best Belfast City Airport said that "we are obviously disappointed at Ryanair's decision; the airline had provided five successful routes from Belfast City Airport".
"However, passenger figures had proved that there was significant demand for the routes operated by Ryanair and I am confident that we can attract other airlines to fill the void," she said.
Ryanair is Europe's largest low-cost airline.
The airline currently flies from George Best Belfast City Airport to five locations in the UK - Bristol, the East Midlands, Glasgow, Liverpool and London.
Ryanair operations from Derry City airport are not affected by Tuesday's decision.
Belfast City airport has wanted to build a runway extension for some time.
According to BBC NI business correspondent Kevin Magee, this would allow Ryanair to fly to destinations much further afield.
"But the extension proposal is now tied up in to the planning process.
"Earlier this month, the Planning Appeals Commission delayed a planned public inquiry into the proposed extension until further information is provided by the airport.
"The objections to the extension centre on environmental, social and economic concerns," said our correspondent.
Click here to view original article by the BBC News, Tuesday 31st August 2010
